Projects 

Most relevant grant funding obtained in relation to the research agenda of the project.

GA 19-05048S Role of exosomes in the communication between associated fibroblasts and tumour cells, with focus on malignant melanoma 

Funding provider: GA0 - Czech Science Foundation (GA CR)
Recipient: Charles University, First Faculty of Medicine
Principal investigator: Prof Karel Smetana Jr, MD DSc


IGA MZ ČR 9049-3 Glycomic analysis of head and neck carcinoma - prognostic significance

Funding provider: Internal Grant Agency of the Ministry of Health of the Czech Republic (IGA MH)
Recipient: First Faculty of Medicine, Charles University 
Principal investigator: Prof Jan Plzák, MD, PhD


NPV II Novel genomic and biotechnological methods in molecular oncology: route to early diagnostics and targeted therapy(2006-2011, MEYS)

Funding provider: Ministry of Education, Youth and Sports of the Czech Republic (MEYS)
Recipient: Institute of Applied Biotechnologys, a.s.; Institute of Molecular Genetics of the ASCR, v. v. i.; First Faculty of Medicine, Charles University
Principal investigator: Prof Tomáš Stopka, MD, PhD


AZV 16-29032A ERK pathway activation as a prognostic tool and a prospective therapeutic target in head and neck squamous cell carcinoma and malignant melanoma, (2016-2019, MZ0)

Funding provider: Ministry of Health of the Czech Republic (MH)
Recipient: Institute of Molecular Genetics of the ASCR, v. v. i.
Principal investigator: Prof Václav Pačes, DS


Support of sustainability of the Institute of Molecular and Translational Medicine, (2014-2019, MEYS LO1304)

Funding provider: Ministry of Education, Youth and Sports of the Czech Republic (MEYS)
Recipient: Palacký University, Olomouc, Faculty of Medicine
Principal investigator: Assoc. Prof Marián Hajdúch, MD, PhD


Centre of Original Drug Design, (2012-2019, TACR TE01020028)

Funding provider: Technology Agency of the Czech Republic (TACR)
Recipient: Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
Principal investigator: Zdeněk Havlas, DSc


Specific ligands for carbohydrate tumour markers: from recognition to diagnosis and therapy, (2014-2016, MEYS LH14008)

Funding provider: Ministry of Education, Youth and Sports of the Czech Republic (MEYS)
Recipient: University of Chemistry and Technology in Prague, Faculty of Chemistry and Engineering
Principal investigator: Prof Vladimír Král, DSc


PROGRES Q28 - Complex Oncology Programme of Charles University 

Funding provider: Charles University
Recipient: First Faculty of Medicine, Charles University
Principal investigator: Prof Aleksi Šedo, MD, DSc


15-31379A Novel concepts of therapeutic targeting of human glioblastoma microenvironment (2015-2019, MH)

Funding provider: Ministry of Health of the Czech Republic (MH)
Recipient: Military University Hospital Prague
Principal investigator: Prof Vladimír Beneš, MD, DSc, Prof Aleksi Šedo, MD, DSc, Robert Tomáš, MD, PhD, Assoc. Prof Jan Konvalinka, PhD


EATRIS-CZ Czech national node of the European infrastructure for translational medicine 

Host institution: Palacký University, Olomouc

Partner institutions: First Faculty of Medicine, Charles University; Masaryk University - Central European Institute of Technology (CEITEC); Institute of Microbiology of the ASCR, v. v. i.; Institute of Experimental Medicine of the ASCR, v. v. i.; Institute of Nuclear Physics of the ASCR, v. v. i.; Institute of Macromolecular Chemistry of the ASCR, v. v. i.; Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.; University of Chemistry and Technology, Prague
Guarantor: Assoc. Prof Marián Hajdúch, MD, PhD


AZV 17-28055A "Identification of the phenotype and function of immune cells as predictors of the treatment response in patients with squamous cell head and neck cancer" (2017-2020)

Funding provider: Ministry of Health of the Czech Republic (MH)
Recipient: Charles University, Faculty of Science
Principal investigator: Ruth Tachezy, PhD


Role of aspartyl beta hydroxylase in human papilloma virus-associated and non-associated tumours (2019-2022), Inter-Excellence, subprogramme Inter-Action LTAUSA18003

Funding provider: Ministry of Education, Youth and Sports of the Czech Republic (MEYS)
Recipient: Charles University, Faculty of Science 
Principal investigator: Ruth Tachezy, PhD


GA 19-00816S Experimental cancer immunotherapy, tumour heterogeneity, and overcoming tumour escape against immune surveillance (2019-2021)

Funding provider: GA0 - Czech Science Foundation (GACR)
Recipient: Charles University, Faculty of Science
Principal investigator: Michal Šmahel, PhD


Role of matrix metalloproteinase and vimentin cooperation for the activity of cancer cell invadopodia

Funding provider: GA0 - Czech Science Foundation (GACR)
Recipient: Charles University, Faculty of Science
Principal investigator: Assoc. Prof Jan Brábek, PhD


Identification of the role of p130Cas protein in mechanical signal transfer at the cell-ECM interface

Funding provider: GA0 - Czech Science Foundation (GACR)
Recipient: Charles University, Faculty of Science
Principal investigator: Assoc. Prof Daniel Rösel, PhD


Substituted imidazopyrimidines: Rational design and development of specific protein kinase inhibitors with anti-cancer effects

Funding provider: GA0 - Czech Science Foundation (GACR)
Recipient: Výzkumný ústav organických syntéz a.s.
Principal investigator: doc. RNDr. Jan Brábek, Ph.D.