Publications

International Journal of Molecular Sciences; published 4 July 2021
Ondřej Kodet, Kristýna Němejcová, Karolína Strnadová, Andrea Havlínová, Pavel Dundr, Ivana Krajsová, Jiří Štork, Karel Smetana, Jr. and Lukáš Lacina
The Abscopal Effect in the Era of Checkpoint Inhibitors


Cancers, published 1 July 2021
Eva Balážiová, Petr Výmola, Petr Hrabal, Rosana Mateu, Zubaľ, Robert Tomáš, David Netuka, Filip Kramář, Zuzana Zemanová, Karla Svobodová, Marek Brabec, Aleksi Šedo and Petr Bušek
Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis


NEW     Cancers, Published: 19 June 2021, Volume 13
Adrianna Piataková, Ingrid Poláková, Jana Šmahelová, Shweta Dilip Johari, Jaroslav Nunvář, Michal Šmahel
Distinct Responsiveness of Tumor-Associated Macrophages to Immunotherapy of Tumors with Different Mechanisms of Major Histocompatibility Complex Class I Downregulation


International Journal of Molecular Sciences; published 18 June 2021
Nikita Abramenko, Fréderic Vellieux, Petra Tesařová, Zdeněk Kejík, Robert Kaplánek, Lukáš Lacina, Barbora Dvořánková, Daniel Rösel, Jan Brábek, Adam Tesař, Milan Jakubek and Karel Smetana, Jr.
Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequence


Molecules; published 9 June 2021
Silvie Rimpelová, Michal Kolář, Hynek Strnad, Tomáš Ruml, Libor Vítek, Helena Gbelcová
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins


NEW     Biomolecules; Published: 20 May 2021, Volume 11
Jaroslav Nunvář, Lucie Pagáčová, Zuzana Vojtěchová, Nayara Trevisan Doimo de Azevedo, Jana Šmahelová, Martina Saláková, Ruth Tachezy
Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas


CANCER GENOMICS & PROTEOMICS; May-Jun 2021; 18
Štěpán Novák, Michal Kolář, Arpád Szabó, Zdena Vernerová, Lukáš Lacina, Hynek Strnad, Jana Šáchová, Miluše Hradilová, Jan Havránek, Michal Španko, Matúš Čoma, Lukáš Urban, Miriam Kaňuchová, Nikola Melegová, Robert Gürlich, Josef Dvořák, Karel Smetana Jr, Peter Gál, Pavol Szabo
Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts


NEW     Cancers; published 16 April 2021 , Volume 13
Julie Vacková, Ingrid Poláková, Shweta Dilip Johari, Michal Šmahel
CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade


The Journal of Immunology; April 20, 2021
Alena Moudrá, Veronika Niederlová, Jiří Novotný, Lucie Schmiedová, Jan Kubovčiak, Tereza Matejková, Aleš Drobek, Michaela Přibíková, Romana Stopková, Dagmar Čížková, Aleš Neuwirth, Juraj Michalík, Kateřina Křížová, Tomas Hudcovic, Michal Kolář, Hana Kozáková, Jakub Kreisinger, Pavel Stopka, Ondřej Štěpánek
Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging)


NEW     Diagnostics; Published: 31 March 2021, Volume 11
Barbora Pokrývková, Jana Šmahelová, Natálie Dalewská, Marek Grega, Ondřej Vencálek, Michal Šmahel, Jaroslav Nunvář, Jan Klozar, Ruth Tachezy
ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas


CHEMICAL BIOLOGY & DRUG DESIGN, Wiley Online Library; February 2021, Volume: 97
Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Ameneh Tatar, Tereza Brogyányi, Martina Pajková, David Sýkora, Kateřina Veselá, Veronika Antonyová, Petr Dytrych, Masao Ikeda-Saito, Pavel Martásek, Milan Jakubek
Spectroscopic study of in situ-formed metallocomplexes of proton pump inhibitors in water


International Journal of Molecular Sciences; 2021, 22(2), published 11. 1. 2021
Zdeněk Kejík, Robert Kaplánek, Michal Masařík, Petr Babula, Adam Matkowski, Petr Filipenský, Kateřina Veselá, Jakub Gburek, David Sýkora, Pavel Martásek, Milan Jakubek
Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond


Melanoma Research; 2021, 31, 140-151
Martin Kertys, Marián Grendár, Vratislav Horák, Nela Žideková, Helena Kupcova Skalniková, Juraj Mokrý, Erika Halasová and Jan Strnadel
Metabolomic characterisation of progression and spontaneous regression of melanoma in the melanoma-bearing Libechov minipig model


Folia Biologica; 66, 142-147 (2020)
V. Lachová, P. Mitrengová, N. Melegová, K. Smetana JR., P. Gál
Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report


Frontiers in Cellular Neuroscience; 2021, Volume 14, January 28, 2021
Jakub Červenka, Jiřina Tylečková, Helena Kupcová Skalníková, Kateřina Vodičková Kepková, Levgeniia Poliakh, Ivona Valeková, Lucie Pfeiferová, Michal Kolář, Michaela Vaškovičová, Tereza Pánková and Petr Vodička
Proteomic Characterization of Human Neural Stem Cells and Their Secretome During in vitro Differentiation 


International Journal of Molecular Sciences; 2021, Volume 22, 21. ledna 2021
Evžen Křepela, Zdislava Vaničková, Petr Hrabal, Michal Zubal´, Barbora Chmielová, Eva Balážiová, Petr Výmola, Ivana Matrasová, Petr Bušek, Aleksi Šedo
Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment 


International Journal of Molecular Sciences; 2021, 18. January 2021
Matúš Čoma, Lucia Fröhlichová, Lukáš Urban, Robert Zajíček, Tomáš Urban, Pavol Szabo, Štěpán Novák, Vitaly Fetissov, Barbora Dvořánková, Karel Smetana Jr., Peter Gál
Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at AllWound Healing Stages (Inflammation, Proliferation and Maturation) 


Molecular Medicine Reports; 2021, accepted October 2, 2020
Peter Gál, Tomáš Vasilenko, Ivan Kováč, Matúš Čoma, Ján Jakubčo, Martina Jakubčová, Vlasta Peržeľová, Lukáš Urban, Michal Kolář, František Sabol, Ján Luczy, Martin Novotný, Jaroslav Majerník, Hans-Joachim Gabius, Karel Smetana Jr
Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo


Cancers; 2020, Volume 12, Issue 11, 3324, 2020/11/10
Jiří Novotný, Karolína Strnadová, Barbora Dvořánková, Šárka Kocourková, Radek Jakša, Pavel Dundr, Václav Pačes, Karel Smetana Jr., Michal Kolář a Lukáš Lacina
Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids


International Journal of Molecular Sciences; 26 October 2020
Jan Brábek, Milan Jakubek, Fréderic Vellieux, Jiří Novotný, Michal Kolář, Lukáš Lacina, Pavol Szabo, Karolína Strnadová, Daniel Rösel, Barbora Dvořánková and Karel Smetana Jr.
Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19


Journal of Experimental & Clinical Cancer Research; Article number 163; 2020
Madiha Kanwal, Michal Šmahel, Mark Olsen, Jana Šmahelová, Ruth Tachezy
Aspartate β-hydroxylase as a target for cancer therapy



Cancers; 3 September 2020
Karel Smetana Jr., Lukáš Lacina, Ondřej Kodet
Targeted Therapies for Melanoma 


Cancers; 28 August 2020
Aneta Gandalovičová, Anna-Marie Šůchová, Vladimír Čermák, Ladislav Merta, Daniel Rösel, Jan Brábek
Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells


International Journal of Oncology; 26 June 2020
Ondřej Kodet, Jan Kučera, Karolína Strnadová, Barbora Dvořánková, Jiří Štork, Lukáš Lacina, Karel Smetana Jr
Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review) 


Applied Materialstoday; Volume 20, available online 6 June 2020
Michaela Fojtů, Jan Balvan, Martina Raudenská, Tomáš Vičar, Jiří Šturala, Zdeněk Sofer, Jan Luxa Jan Plutnara, Michal Masařík, Martin Pumera
2D Germanane Derivative as a Vector for Overcoming Doxorubicin Resistance in Cancer Cells

Scientific Data; Volume 7 no. 160; 27 May 2020
Vladimír Čermák, Aneta Gandalovičová, Ladislav Merta, Karel Harant, Daniel Rösel, Jan Brábek
High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen


DNA Repair; Volumes 91-92, available online 21 May 2020

Veronika Antonyová, Zdeněk Kejík, Tereza Brogyányi, Robert Kaplánek, Martina Pajková, Veronika Talianová, Róbert Hromádka, Michal Masařík, David Sýkora, Lucie Mikšátková, Pavel Martásek, Milan Jakubek
Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease


European Journal of Cell Biology; Volume 99; May 2020
Vladimír Čermáka, Vojtěch Dostál, Michael Jelínek, Lenka Libusová, Jan Kovář, Daniel Rösel, Jan Brábek
Microtubule-targeting agents and their impact on cancer treatment


Journal of Cheminformatics; Volume 12, 20 May 2020
Milan Voršilák, Michal Kolář, Ivan Čmelo & Daniel Svozil
SYBA: Bayesian estimation of synthetic accessibility of organic compounds 


IN VIVO; 2020 vol. 34 no. 3
Karel Smetana Jr., Jan Brábek
Role of Interleukin-6 in Lung Complications in Patients with COVID-19: Therapeutic Implications


Anticancer Research International Journal of Cancer Research and Treatment; 2020, April 23
Lenka Varinská, Lenka Fáber, Eva Petrovová, Ludmila Balážová, Eleonóra Ivančová, Michal Kolář a Peter Gál
Galectin-8 Favors VEGF-Induced Angiogenesis: In Vitro Study in Human Umbilical Vein Endothelial Cells and In Vivo Study in Chick Chorioallantoic Membrane


Applied Sciences; 2020, 9 April
Marek Feith, Tomáš Vičar, Jaromír Gumulec, Martina Raudenská, Anette Gjörloff Wingren, Michal Masařík, Jan Balvan
Quantitative Phase Dynamics of Cancer Cell Populations Affected by Blue Light


Biochimica et Biophysica Acta; Volume 1868, Issue 7; Online 6 April 2020
Adéla Šimková, Petr Bušek, Aleksi Šedo, Jan Konvalinka
Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications 


Histochemistry and Cell Biology; 30 March 2020
Karolína Strnadová, Michal Španko, Barbora Dvořánková, Lukáš Lacina, Ondřej Kodet, Andrej Shbat, Ivo Klepáček, Karel Smetana Jr
Melanoma xenotransplant on the chicken chorioallantoic membrane: a complex biological model for the study of cancer cell behaviour 


International Journal of Cancer; 03/2020
Martina Raudenská, Jaromír Gumulec, Jan Balvan, Michal Masařík 
Caveolin‐1 in oncogenic metabolic symbiosis


Dyes and Pigments; Volume 172, January 2020
Lucie Krčová, Silvie Rimpelová, Martin Havlík, Bohumil Dolenský, Frédéric Vellieux, Tomáš Ruml, Pavel Martásek, Vladimír Král, Tomáš Bříza
Highly selective mitochondrial probes based on fluorinated pentamethinium salts: On two-photon properties and microscopic applications


Bioorganic Chemistry; Volume 94, January 2020
Veronika Talianová, Tomáš Bříza, Lucie Krčová, Bohumil Dolenský, Jarmila Králová, Pavel Martásek, Vladimír Král, Martin Havlík
Dedicated to the memory of Professor Vladimír Král.
Coumarin Tröger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes


Cell press, Trends in Cancer; 2019, 12/1
Daniel Rösel, Michael Fernandes, Victoria Sanz-Moreno, Jan Brábek
Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?


Cancer; 2020, 11/1
Kateřina Strouhalová, Magdaléna Přechová, Aneta Gandalovičová, Jan Brábek, Martin Gregor, Daniel Rösel
Vimentin Intermediate Filaments as Potential Target for Cancer Treatment 


International Journal of Molecular Sciences; 3/2020
Julie Vacková, Adrianna Piataková, Ingrid Poláková, Michal Šmahel
Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade


Biomedicine & Pharmacotherapy; Volume 118, October 2019
Milan Jakubek, Zdeněk Kejík, Robert Kaplánek, Róbert Hromádka, Viera Šandriková, David Sýkora, Veronika Antonyová, Marian Urban, Petr Dytrych, Ivan Mikula, Pavel Martásek, Vladimír Král
Strategy for improved therapeutic efficiency of curcumin in the treatment of gastric cancer 


Cancer; 2020, 12/4
Jiří Novotný, Veronika Bandúrová, Hynek Strnad, Martin Chovanec, Miluše Hradilová, Jana Šáchová, Martin Šteffl, Josipa Grušanović, Roman Kodet, Václav Pačes, Lukáš Lacina, Karel Smetana Jr., Jan Plzák, Michal Kolář, Tomáš Vomastek
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2



BOOK: Immune Mediators in Cancer; Humana Press 2020
Ivana Vancurova, Yan Zhu

Part of the book: Luminex xMAP Assay to Quantify Cytokines in Cancer Patient Serum
Helena Kupcová Skalníková, Kateřina Vodičková Kepková, Petr Vodička


Viruses; 12/2019
Barbora Pokrývková, Martina Saláková, Jana Šmahelová, Zuzana Vojtěchová, Vendula Novosadová, Ruth Tachezy
Detailed Characteristics of Tonsillar Tumors with Extrachromosomal or Integrated Form of Human Papillomavirus


Oncology Reports; 12/2019

Karolína Lhotaková, Adrianna Grzelak, Ingrid Poláková, Julie Vacková, Michal Šmahel
Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules


BIOPROSPECT; 29th Volume, No. 4/2019
Peter Vanek, Helena Kupcová Skalníková
EXTRACELULÁRNÍ VÁČKY A JEJICH BIOMEDICÍNSKÝ POTENCIÁL 


GENES - Open Access Journal; 9. 11. 2019
Vratislav Horák, Anna Palanová, Jana Čížková, Veronika Miltrová, Petr Vodička, Helena Kupcová Skalniková
Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma


BIOPROSPECT; 29th Volume, No. 3/2019
Anna Palánová, Helena Kupcová Skalníková
NEKÓDUJÍCÍ RNA A MALIGNÍ MELANOM 


ONCOLOGY REPORTS; 17. 9. 2019 
Jan Kučera, Karolína Strnadová, Barbora Dvořánková, Lukáš Lacina, Ivana Krajsová, Jiří Štork, Hana Kovářová, Helena Kupcová Skalníková, Petr Vodička, Jan Motlík, Pavel Dundr, Karel Smetana, Ondřej Kodet
Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study


Clinics in Dermatology; July - August 2019
Karolína Strnadová, Vojtěch Šandera, Barbora Dvořanková, Ondřej Kodet, Markéta Dušková, Karel Smetana, Lukáš Lacina
Skin aging: the dermal perspective


Folia Biologica; 2019
I. Šušaníková, M. Puchľová, V. Lachová, E. Švajdlenka, P. Mučaji, K. Smetana Jr., P. Gál
Genistein and Selected Phytoestrogen-Containing Extracts Differently Modulate Antioxidant Properties and Cell Differentiation: an in Vitro Study in NIH-3T3, HaCaT and MCF-7 Cells


Cells; May 2019
Vít Všianský, Markéta Svobodová, Jaromír Gumulec, Natália Cernei, Dagmar Štěrbová, Ondřej Zítka, Rom Kostřica, Pavel Smilek, Jan Plzák, Jan Betka, David Kalfeřt, Michal Masařík, Martina Raudenská
Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers 


Proteomes; April 2019
Helena Kupcová Skalníková, Božena Bohuslavová, Karolína Turnovcová, Jana Juhásová, Štefan Juhás, Marie Rodinová and Petr Vodička
Isolation and Characterization of Small Extracellular Vesicles from Porcine Blood Plasma, Cerebrospinal Fluid, and Seminal Plasma 


Molecular Cancer; March 2019
Barbora Peltanová, Martina Raudenská, Michal Masařík
Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review


Cancers - Open Access Journal; March 2019
Jan Plzák, Jan Bouček, Veronika Bandúrová, Michal Kolář, Miluše Hradilová, Pavol Szabo, Lukáš Lacina, Martin Chovanec a Karel Smetana Jr.
The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy  


Cell Chemical Biology; February 2019
Lenka Koudelková, Andreea Csilla Pataki, Ondřej Tolde, Vojtěch Pavlík, Max Nobis, Jakub Gemperle, Kurt Anderson, Jan Brábek, Daniel Rösel
Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions


Molecular Oncology; February 2019
Jakub Gemperle, Michal Dibus, Lenka Koudelková, Daniel Rösel, Jan Brábek
The interaction of p130Cas with PKN3 promotes malignant growth


Royal Society of Chemistry, Chemical Communications; January 2019
Martin Havlík, Veronika Talianová, Robert Kaplánek, Tomáš Bříza, Bohumil Dolenský, Jarmila Králová, Pavel Martásekd a Vladimír Král
Versatile fluorophores for bioimaging applications: π-expanded naphthalimide derivatives with skeletal and appendage diversity


Anticancer Research International Journal of Cancer Research and Treatment; November 2018; Lukáš Lacina, Matúš Čoma, Barbora Dvořánková, Ondřej Kodet, Nikola Melegová, Peter Gál a Karel Smetana Jr.
Evolution of Cancer Progression in the Context of Darwinism