Publications

NEW     Pharmaceutics 2022, 14, Published 17 August 2022
Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo 6, Karel Smetana, Jr.; Milan Jakubek
New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity

Histochemistry and Cell Biology; 2022, Published 22 July 2022
Peter Gál, Jan Brábek, Michal Holub, Milan Jakubek, Aleksi, Lukáš Lacina, Karolína Strnadová, Petr Dubový, Helena Hornychová, Aleš Ryška, Karel Smetana Jr.
Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of inflammation

Veterinary Sciences 2022, 9(5), Published 16 May 2022
Petra Adamková, Petra Hradická, Helena Kupcová Skalníková, Veronika Čížková, Petr Vodička, Silvia Farkašová Iannaccone, Monika Kassayová, Soňa Gancarčiková, Vlasta Demečková
Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease

Cancers 2022, 14(9), Published 3 May 2022
Barbora Peltanová, Hana Holcová Polanská, Martina Raudenská, Jan Balvan, Jiří Navrátil, Tomáš Vičar, Jaromír Gumulec, Barbora Čechová, Martin Kräter, Jochen Guck, David Kalfeřt, Marek Grega, Jan Plzák, Jan Betka, Michal Masařík
mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells

In Vivo; Vol. 36, Issue 3 May-June 2022
TOMÁŠ VASILENKO, IVAN KOVÁČ, MARTIN SLEZÁK, JÁN ĎURKÁČ, VLASTA PERŽEL'OVÁ, MATÚŠ ČOMA, MIRIAM KAŇUCHOVÁ, LUKÁŠ URBAN, PAVOL SZABO, BARBORA DVOŘÁNKOVÁ, ANDREJ VRZGULA, ROBERT ZAJÍČEK, KAREL SMETANA a PETER GÁL
Agrimonia eupatoria L. Aqueous Extract Improves Skin Wound Healing: An In Vitro Study in Fibroblasts and Keratinocytes and In Vivo Study in Rats

Cancers 2022, published 21 April 2022
Petr Bušek, Jonathan S. Duke-Cohan, Aleksi Šedo
Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease?

International Journal of Molecular Sciences 23, Published 7 April 2022
Karel Smetana, Jr., Michal Masařík
Advances in Cancer Metabolism and Tumour Microenvironment

BMC Microbiology 22, Number: 63 (2022), published 25 February 2022
Chahrazed Mekadim, Helena Kupcová Skalníková, Jana Čížková, Veronika Cizkova, Anna Palánová, Vratislav Horák and Jakub Mrazek
Dysbiosis of skin microbiome and gut microbiome in melanoma progression

International Journal of Molecular Sciences 23, published 16 January  2022
Martin Vokurka, Lukáš Lacina, Jan Brábek, Michal Kolář, Yi Zhen Ng, Karel Smetana, Jr.
Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Histochemistry and Cell Biology, published 27 November 2021
Karolína Strnadová, Lucie Pfeiferová, Petr Přikryl, Barbora Dvořánková, Erik Vlčák, Jana Frýdlová, Martin Vokurka, Jiří Novotný, Jana Šáchová, Miluše Hradilová, Jan Brábek, Jana Šmigová, Daniel Rösel, Karel Smetana Jr., Michal Kolář, Lukáš Lacina
Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer‑associated fibroblasts

Pharmaceutics 2021, 13, published 5 November 2021
Zdeněk Kejík, Robert Kaplánek, Petr Dytrych, Michal Masařík, Kateřina Veselá, Nikita Abramenko, David Hoskovec, Martina Vašáková, Jarmila Králová, Pavel Martásek, Milan Jakubek
Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Molecular Cancer; 20, Number: 140 (2021), published 27 October 2021
Martina Raudenská, Jan Balvan, Michal Masařík
Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers

International Journal of Molecular Sciences 22, Published 13 October 2021
Michal Španko, Karolína Strnadová, Aleš Jan Pavlíček, Pavol Szabo, Ondřej Kodet, Jaroslav Valach, Barbora Dvořánková, Karel Smetana, Jr. and Lukáš Lacina
IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

PHYSIOLOGICAL RESEARCH; published 10 September 2021
Miriam KAŇUCHOVÁ, Lukáš URBAN, Nikola MELEGOVÁ, Matúš ČOMA, Barbora DVOŘÁNKOVÁ, Karel SMETANA JR., Peter GÁL
Genistein does not Inhibit TGF-β1-Induced Conversion of Human Dermal Fibroblasts to Myofibroblasts

Cells, 2021, 10(8), Published 21 July 2021
Jonathan Solomon, Magdalena Rašková, Daniel Rösel, Jan Brábek, Hava Gil-Henn
Are We Ready for Migrastatics?

PLOS Genetics, 17(7), Published 7 July 2021
Qifei Li, Michal Dibus, Alicia Casey, Christina S. K. Yee, Sara O. Vargas, Shiyu Luo, Samantha M. Rosen, Jill A. Madden, Casie A. Genetti, Jan Brábek, Catherine A. Brownstein, Shideh Kazerounian, Benjamin A. Raby, Klaus Schmitz-Abe, John C. Kennedy, Martha P. Fishman, Mary P. Mullen, Joan M. Taylor, Daniel Rösel, Pankaj B. Agrawal
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

International Journal of Molecular Sciences; Published 4 July 2021
Ondřej Kodet, Kristýna Němejcová, Karolína Strnadová, Andrea Havlínová, Pavel Dundr, Ivana Krajsová, Jiří Štork, Karel Smetana, Jr. and Lukáš Lacina
The Abscopal Effect in the Era of Checkpoint Inhibitors

Cancers, published 1 July 2021
Eva Balážiová, Petr Výmola, Petr Hrabal, Rosana Mateu, Zubaľ, Robert Tomáš, David Netuka, Filip Kramář, Zuzana Zemanová, Karla Svobodová, Marek Brabec, Aleksi Šedo and Petr Bušek
Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis

Biology Open; Published June 28, 2021, Volume 10, Issue 8
Rita Suchá, Martina Kubičková, Jakub Červenka, Marián Hruška-Plochan, Dáša Bohačiaková, Kateřina Vodičková Kepková, Tereza Nováková, Kateřina Budková, Andrej Šušor, Martin Marsala, Jan Motlík, Hana Kovarová, Petr Vodička
Targeted mass spectrometry for monitoring of neural differentiation

Cancers, Published: 19 June 2021, Volume 13
Adrianna Piataková, Ingrid Poláková, Jana Šmahelová, Shweta Dilip Johari, Jaroslav Nunvář, Michal Šmahel
Distinct Responsiveness of Tumor-Associated Macrophages to Immunotherapy of Tumors with Different Mechanisms of Major Histocompatibility Complex Class I Downregulation

International Journal of Molecular Sciences; published 18 June 2021
Nikita Abramenko, Fréderic Vellieux, Petra Tesařová, Zdeněk Kejík, Robert Kaplánek, Lukáš Lacina, Barbora Dvořánková, Daniel Rösel, Jan Brábek, Adam Tesař, Milan Jakubek and Karel Smetana, Jr.
Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequence

Molecules; published 9 June 2021
Silvie Rimpelová, Michal Kolář, Hynek Strnad, Tomáš Ruml, Libor Vítek, Helena Gbelcová
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins

Biomolecules; Published: 20 May 2021, Volume 11
Jaroslav Nunvář, Lucie Pagáčová, Zuzana Vojtěchová, Nayara Trevisan Doimo de Azevedo, Jana Šmahelová, Martina Saláková, Ruth Tachezy
Lack of Conserved miRNA Deregulation in HPV-Induced Squamous Cell Carcinomas

CANCER GENOMICS & PROTEOMICS; May-Jun 2021; 18
Štěpán Novák, Michal Kolář, Arpád Szabó, Zdena Vernerová, Lukáš Lacina, Hynek Strnad, Jana Šáchová, Miluše Hradilová, Jan Havránek, Michal Španko, Matúš Čoma, Lukáš Urban, Miriam Kaňuchová, Nikola Melegová, Robert Gürlich, Josef Dvořák, Karel Smetana Jr, Peter Gál, Pavol Szabo
Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts

Cancers; published 16 April 2021 , Volume 13
Julie Vacková, Ingrid Poláková, Shweta Dilip Johari, Michal Šmahel
CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade

The Journal of Immunology; April 20, 2021
Alena Moudrá, Veronika Niederlová, Jiří Novotný, Lucie Schmiedová, Jan Kubovčiak, Tereza Matejková, Aleš Drobek, Michaela Přibíková, Romana Stopková, Dagmar Čížková, Aleš Neuwirth, Juraj Michalík, Kateřina Křížová, Tomas Hudcovic, Michal Kolář, Hana Kozáková, Jakub Kreisinger, Pavel Stopka, Ondřej Štěpánek
Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging)

PHYSIOLOGICAL RESEARCH; Published April 6, 2021, Volume 70, Issue 2
Lukáš Lacina, Jan Brábek , Šárka Fingerhutová, Jiří Zeman, Karel Smetana Jr.
Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential Role for Cytokines Such Is IL-6

Diagnostics; Published: 31 March 2021, Volume 11
Barbora Pokrývková, Jana Šmahelová, Natálie Dalewská, Marek Grega, Ondřej Vencálek, Michal Šmahel, Jaroslav Nunvář, Jan Klozar, Ruth Tachezy
ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas

Cell Death & Disease; 2, Number: 192 (2021); Published 18 February 2021
Martina Raudenská, Jan Balvan, Michal Masařík
Cell death in head and neck cancer pathogenesis and treatment

CHEMICAL BIOLOGY & DRUG DESIGN, Wiley Online Library; February 2021, Volume: 97
Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Ameneh Tatar, Tereza Brogyányi, Martina Pajková, David Sýkora, Kateřina Veselá, Veronika Antonyová, Petr Dytrych, Masao Ikeda-Saito, Pavel Martásek, Milan Jakubek
Spectroscopic study of in situ-formed metallocomplexes of proton pump inhibitors in water

International Journal of Molecular Sciences; 2021, 22(2), published 11. 1. 2021
Zdeněk Kejík, Robert Kaplánek, Michal Masařík, Petr Babula, Adam Matkowski, Petr Filipenský, Kateřina Veselá, Jakub Gburek, David Sýkora, Pavel Martásek, Milan Jakubek
Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Folia Biologica; 66, 142-147 (2020)
V. Lachová, P. Mitrengová, N. Melegová, K. Smetana JR., P. Gál
Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report

Frontiers in Cellular Neuroscience; 2021, Volume 14, January 28, 2021
Jakub Červenka, Jiřina Tylečková, Helena Kupcová Skalníková, Kateřina Vodičková Kepková, Levgeniia Poliakh, Ivona Valeková, Lucie Pfeiferová, Michal Kolář, Michaela Vaškovičová, Tereza Pánková and Petr Vodička
Proteomic Characterization of Human Neural Stem Cells and Their Secretome During in vitro Differentiation 

International Journal of Molecular Sciences; 2021, 18. January 2021
Matúš Čoma, Lucia Fröhlichová, Lukáš Urban, Robert Zajíček, Tomáš Urban, Pavol Szabo, Štěpán Novák, Vitaly Fetissov, Barbora Dvořánková, Karel Smetana Jr., Peter Gál
Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at AllWound Healing Stages (Inflammation, Proliferation and Maturation) 

Molecular Medicine Reports; 2021, accepted October 2, 2020
Peter Gál, Tomáš Vasilenko, Ivan Kováč, Matúš Čoma, Ján Jakubčo, Martina Jakubčová, Vlasta Peržeľová, Lukáš Urban, Michal Kolář, František Sabol, Ján Luczy, Martin Novotný, Jaroslav Majerník, Hans-Joachim Gabius, Karel Smetana Jr
Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo

Cancers; 2020, Volume 12, Issue 11, 3324, 2020/11/10
Jiří Novotný, Karolína Strnadová, Barbora Dvořánková, Šárka Kocourková, Radek Jakša, Pavel Dundr, Václav Pačes, Karel Smetana Jr., Michal Kolář a Lukáš Lacina
Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids

International Journal of Molecular Sciences; 26 October 2020
Jan Brábek, Milan Jakubek, Fréderic Vellieux, Jiří Novotný, Michal Kolář, Lukáš Lacina, Pavol Szabo, Karolína Strnadová, Daniel Rösel, Barbora Dvořánková and Karel Smetana Jr.
Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Journal of Experimental & Clinical Cancer Research; Article number 163; 2020
Madiha Kanwal, Michal Šmahel, Mark Olsen, Jana Šmahelová, Ruth Tachezy
Aspartate β-hydroxylase as a target for cancer therapy

in vivo; September-October 2020 vol. 34
Karel Smetana Jr., Daniel Rösel, Jan Brábek
Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality

Cancers; 3 September 2020
Karel Smetana Jr., Lukáš Lacina, Ondřej Kodet
Targeted Therapies for Melanoma 

Cancers; 28 August 2020
Aneta Gandalovičová, Anna-Marie Šůchová, Vladimír Čermák, Ladislav Merta, Daniel Rösel, Jan Brábek
Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

International Journal of Oncology; 26 June 2020
Ondřej Kodet, Jan Kučera, Karolína Strnadová, Barbora Dvořánková, Jiří Štork, Lukáš Lacina, Karel Smetana Jr
Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review) 

Scientific Data; Volume 7 no. 160; 27 May 2020
Vladimír Čermák, Aneta Gandalovičová, Ladislav Merta, Karel Harant, Daniel Rösel, Jan Brábek
High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

European Journal of Cell Biology; Volume 99; May 2020
Vladimír Čermáka, Vojtěch Dostál, Michael Jelínek, Lenka Libusová, Jan Kovář, Daniel Rösel, Jan Brábek
Microtubule-targeting agents and their impact on cancer treatment

IN VIVO; 2020 vol. 34 no. 3
Karel Smetana Jr., Jan Brábek
Role of Interleukin-6 in Lung Complications in Patients with COVID-19: Therapeutic Implications

Anticancer Research International Journal of Cancer Research and Treatment; 2020, April 23
Lenka Varinská, Lenka Fáber, Eva Petrovová, Ludmila Balážová, Eleonóra Ivančová, Michal Kolář a Peter Gál
Galectin-8 Favors VEGF-Induced Angiogenesis: In Vitro Study in Human Umbilical Vein Endothelial Cells and In Vivo Study in Chick Chorioallantoic Membrane

Biochimica et Biophysica Acta; Volume 1868, Issue 7; Online 6 April 2020
Adéla Šimková, Petr Bušek, Aleksi Šedo, Jan Konvalinka
Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications 

Histochemistry and Cell Biology; 30 March 2020
Karolína Strnadová, Michal Španko, Barbora Dvořánková, Lukáš Lacina, Ondřej Kodet, Andrej Shbat, Ivo Klepáček, Karel Smetana Jr
Melanoma xenotransplant on the chicken chorioallantoic membrane: a complex biological model for the study of cancer cell behaviour 

Cancer; 2020, 11/1
Kateřina Strouhalová, Magdaléna Přechová, Aneta Gandalovičová, Jan Brábek, Martin Gregor, Daniel Rösel
Vimentin Intermediate Filaments as Potential Target for Cancer Treatment 

Cancer; 2020, 12/4
Jiří Novotný, Veronika Bandúrová, Hynek Strnad, Martin Chovanec, Miluše Hradilová, Jana Šáchová, Martin Šteffl, Josipa Grušanović, Roman Kodet, Václav Pačes, Lukáš Lacina, Karel Smetana Jr., Jan Plzák, Michal Kolář, Tomáš Vomastek
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

British Journal of Cancer; 8/2019
Michael Fernandes, Daniel Rosel, Jan Brábek
Solid cancer: the new tumour spread endpoint opens novel opportunities

Viruses; 12/2019
Barbora Pokrývková, Martina Saláková, Jana Šmahelová, Zuzana Vojtěchová, Vendula Novosadová, Ruth Tachezy
Detailed Characteristics of Tonsillar Tumors with Extrachromosomal or Integrated Form of Human Papillomavirus

Oncology Reports; 12/2019

Karolína Lhotaková, Adrianna Grzelak, Ingrid Poláková, Julie Vacková, Michal Šmahel
Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules

BIOPROSPECT; 29th Volume, No. 4/2019
Peter Vanek, Helena Kupcová Skalníková
EXTRACELULÁRNÍ VÁČKY A JEJICH BIOMEDICÍNSKÝ POTENCIÁL 

GENES - Open Access Journal; 9. 11. 2019
Vratislav Horák, Anna Palanová, Jana Čížková, Veronika Miltrová, Petr Vodička, Helena Kupcová Skalniková
Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma

BIOPROSPECT; 29th Volume, No. 3/2019
Anna Palánová, Helena Kupcová Skalníková
NEKÓDUJÍCÍ RNA A MALIGNÍ MELANOM 

ONCOLOGY REPORTS; 17. 9. 2019 
Jan Kučera, Karolína Strnadová, Barbora Dvořánková, Lukáš Lacina, Ivana Krajsová, Jiří Štork, Hana Kovářová, Helena Kupcová Skalníková, Petr Vodička, Jan Motlík, Pavel Dundr, Karel Smetana, Ondřej Kodet
Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study

Folia Biologica; 2019
I. Šušaníková, M. Puchľová, V. Lachová, E. Švajdlenka, P. Mučaji, K. Smetana Jr., P. Gál
Genistein and Selected Phytoestrogen-Containing Extracts Differently Modulate Antioxidant Properties and Cell Differentiation: an in Vitro Study in NIH-3T3, HaCaT and MCF-7 Cells